The Chevrons are the only team of the four remaining West Riding County Amateur League clubs left in the competition not to have lifted the cup.
And their local West Yorkshire League rivals will prove tough opponents, having already beaten them in the Keighley Cup this season.
Bay Athletic, who have twice won the trophy, host Yorkshire Amateur League side Gildersome Spurs OB, while Ovenden West Riding and Storthes Hall, who between them have picked up the cup six times, meet at Natty Lane.
Campion Reserves are the only County Amateur side left in the West Riding County FA Challenge Trophy. They welcome Rothwell Town.
In the league, Tyersal are keen to ease their relegation fears by completing the double at home to Campion, whom they beat 5-0 earlier in the season.
Salts are at home to second-bottom Lepton Highlanders.