Scruton has not featured for the first-team since he sustained a shoulder injury during the win at Hull KR on March 10 which required a reconstruction operation.
Fellow prop Kopczak is also fit again after an ankle injury which has forced him to miss the last six games.
Brett Kearney, who was replaced at half-time during last week's defeat at Leeds due to concussion, is also included as the Bulls take the field for the first time since being docked six points.
Second-rower Olivier Elima is absent due to a shoulder injury but the Bulls are in otherwise rude health as they seek to reignite their play-off hopes.
Bulls squad: Ainscough, Scruton, Lulia, Whitehead, Addy, Burgess, Jeffries, Walker, Hargreaves, Olbison, L’Estrange, Pryce, Platt, Sammut, Gale, Langley, Kearney, Kopczak, Manuokafoa